Hi Neil,
I've been a daily runner for about 13 years now. Running 4-6 miles a day, nothing too fast, 10 min. miles are my average. I did the Suzuki Marathon a five years ago and my trainer told me when I get tired just slow down, but whatever you don't stop. Did I listen....no. I had a cramp at mile 21 and stopped to have it rubbed out and almost couldn't get started again. So my best advice is when you're tired, just slow down. If you get a stitch in your side, bend down to pick up a rock. I'm not sure why it works, but it does.
I'm sure Java will have some newer advice for you.
Happy running!!
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