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Old 03-11-2012, 06:29 AM
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Default Baclofen is a great drug, but is also extremely deadly

I was digging up some information about Baclofen, and found this site. I like to see and hear all the great things its doing to people. Im glad the drug has a very positive output. But also remember, it is a drug, and is EXTREMELY dangerous. I know this first hand. Baclofen put me in a 52 hour coma, and nearly killed me 3 times all within a 5 hour period. You might want to listen to my story, just to be sure you dont make the same mistake I did.

Last Monday night, March the 5th, I overdosed on Baclofen. It started out with me and my friend, James Watts, decided to make an hour and a half long road trip Monday morning. Just to make things easier, we both decided for me just to sleep over at his house Sunday night, and before the crack of dawn, get up and get going. All through that day and night was fine. But when I decided to lay down to get some sleep around 11 PM, I started getting some bad aches and pains. I took a few (3) hydrocodone, just to ease the pain a little. The pain started to ease. But yet I still could not sleep. Finally it reached around 2 AM, and I had thought that maybe getting a little high would put me right to sleep. Sadly enough, I was all out of mary-jane. Tfen I remembered seeing a large bottle of 20 mg. Baclofen. I googled the side effects, and one man stated that if you take roughly 180 mg. at one time, then wait an hour and take another 180 mg, you would get a high similar to that of marijuana. So I was immediately like hell yeah. I downed 9 pills, waited an hour and downed another 9. Not realizing that the Baclofen was going to react to the hydrocodone. (Hydrocodone is very similar to that of regular Tylenol). I was feeling awesome for a while. Yet, I still could not sleep. Luckily, the high made time just fly by. I went on with my business feeling awesome till about 10AM, Monday morning. I started feeling real sick, like I needed to vomit. We were already on the road at this point. I told James I was going to close my eyes for a while, which he didnt mind. Next thing I know, I wake up on James bed, soaked in my own urine, with him screaming at me, " Dude whats wrong with you?!? Im calling an ambulance!!!". Heres the fun part, when i woke up, it was 5 PM, Monday afternoon. I tried waking up, but I just couldnt seem to gather the energy. Eventually I was able to stand up, but immediately I collapsed, and fell back asleep. The next time I woke up, it was Thursday night. My body locked into a coma when I collapsed. Apparently, right before I went into the coma, I had a major seazer. The doctors said if I hadnt of gotten to the hospital before 7 PM, I would most definitely died. While I was in a coma, my entire system started backfiring, and everything that was left keeping me alive, was shutting down. That happened three times within a small amount of time. The next two days I spent doing nothing but resting, trying to what was left of the drugs out of my system. The doctor said the I had absorbed way too much Baclofen, way more than what my body could handle. And it being mixed with the hydrocodone somehow made things worsen tenfold. The doctor said I came so close to the edge of death, he said it was almost useless to try to revive me.

The moral of my story is, just be careful of what you mix together. Ask your doctor if its okay to take certain things with Baclofen. And always pay attention to how strong the dosage is. See, I wasnt thinking about what I was doing. I didnt realize that yes, that other man could take that much drugs at once. But thats because his body and mind is adapted to it. That was the first time I even heard of Baclofen. So dont peel off more food than what you can eat.
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Old 03-11-2012, 06:49 AM
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Im not sure what your point is, but its not baclofen thats dangerous in this case but the way you took it. All drugs are dangerous if you mix them and take to excess.
Glad you are OK tho.
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Old 03-11-2012, 02:03 PM
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Much of this story is highly suspect.

Baclofen does not cause organ failure.

From: Baclofen overdose: defining the spectrum... [Emerg Med Australas. 2006] - PubMed - NCBI

Baclofen overdose: defining the spectrum of toxicity.
Leung NY, Whyte IM, Isbister GK.
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Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia.
Abstract
OBJECTIVES:

To describe the spectrum of toxicity of baclofen in overdose, and investigate dose-related clinical effects.
METHODS:

Consecutive baclofen overdoses were identified from a prospective database of all poisoning admissions presenting to a regional toxicology service. Ingestion was corroborated on more than one occasion and from multiple sources. Demographic, clinical and outcome variables were extracted for each presentation for a retrospective review, and the data sets were divided into high dose (> or = 200 mg) and low dose (< 200 mg) groups for comparison of clinical effects.
RESULTS:

There were 23 presentations, of which eight patients ingested baclofen alone. Seizures were reported in four cases, a decreased level of consciousness (GCS < 9) occurred in eight patients and delirium was recorded in eight patients. Five patients had miosis and seven patients had dilated pupils, 13 patients had absent or depressed reflexes. The only arrhythmias were sinus bradycardia in six patients and sinus tachycardia in five. Hypertension occurred in 13 patients and hypotension in one. The reported total ingested dose of baclofen was known in 19 patients (Mean 630 mg, SD 730 mg; 80-2500 mg). A higher ICU admission rate, rate of mechanical ventilation and prolonged length of stay occurred in those ingesting 200 mg or more. Coma, delirium and seizures occurred only with doses of 200 mg or more, and hypertension was more common with higher doses.
CONCLUSIONS:

Baclofen overdose causes mainly neurological effects and excepting hypertension cardiovascular effects were uncommon. Doses greater than 200 mg were predictive of patients developing delirium, coma and seizures, requiring long hospital admissions and ICU admission.

And if you actually read the full text article nearly all of the patients who had to ventilated (because of coma/consciousness) had baclofen doses ranging from 375-2500mg *and* significant coingestants like alcohol or other CNS depressants.

Tylenol (acetaminophen/paracetamol) is much more toxic and dangerous than baclofen and absolutely causes liver failure and death in overdose. In all of the literature I've combed through (including intentional baclofen overdose in the magnitude of GRAMS) I can think of only one case where baclofen was attributed to cause of death.....oh, there's this from pubmed:

Toxicological analysis of a fatal baclofen (L... [J Forensic Sci. 1991] - PubMed - NCBI

Toxicological analysis of a fatal baclofen (Lioresal) ingestion.
Fraser AD, MacNeil W, Isner AF.
Source

Toxicology Laboratory, Victoria General Hospital, Nova Scotia, Canada.
Abstract

A fatality following ingestion of the drug baclofen (Lioresal) is described. Baclofen was identified in urine by gas chromatography/mass spectrometry. After derivatization with trinitrobenzene sulfonic acid, baclofen was quantitated in serum and urine by high-performance liquid chromatography. The concentration of baclofen was 17 mg/L in serum and 760 mg/L in urine collected approximately 12 h after the overdose. To our knowledge, this is only the second reported fatality involving a baclofen overdose. The previous case did not include quantitation of baclofen in any biological fluid.

PMID:
1955846
[PubMed - indexed for MEDLINE]



-tk

Last edited by terryk; 03-11-2012 at 02:16 PM..
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Old 03-11-2012, 02:05 PM
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Don't know who you are or why you are here but seriously, just go away. Loser.


Missy
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Old 03-11-2012, 02:41 PM
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You ROCK, tk!!
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Old 03-15-2012, 12:28 AM
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People like you is why drugs become illegal. You go on a whim, without any additional sources, decide to take extreme amounts of a drug, which you have never used or experienced before. While mixing it with another CN depressant without any fucking care whatsoever.

The moral of the story here is, if you're a fucking idiot: Do not use drugs.
Do not use drugs that you have NO to limited knowledge about. In way than excessive amounts.

You're one of those people who have to be told that you can die from drinking too much water aren't you?

Please stop using drugs. Forever. You're an idiot and you're lucky to be alive.
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Old 03-15-2012, 01:42 AM
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Fixmyself,
I'm fairly new "again" on this forum after a 3 year hiatus. My purpose here is not to entirely defend the original poster of this thread. Obviously, he was looking for a way for baclofen to get him high, in some sense, and is still an addict, probably in more than one drug, based upon his post.

I'm assuming that all of us on here are addicts, probably have fallen off the wagon more than once, and need help to various degrees. I can't determine if this person is a loser or not, based upon his post. I have lost a lot in life but I've gained in much. Financially, I may be considered a winner, but chemically and personally, I may be considered a loser. I'm not ready to accept that as my final standing in life, therefore I need to improve. This is why I came to this forum.

Certainly, this poster may be an imposter, and I've seen several of those who apparently are. But let's give this addict, like us?, certainly me, the benefit of the doubt and give him support and guidance, at least at first, until he/she continues to prove insolent or non responsive.

I may be wrong, but let's see the good in people, even at first we see the worst. After much deliberation, we can then make a value judgement, based upon evidence.

I appreciate you,

Chili
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Old 03-15-2012, 01:46 AM
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I'm truly sorry fix, it was missabby1 who stated "loser". My sincere apology to you.
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Old 04-14-2013, 05:24 AM
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Shame on the other posters who interpreted this member`s post by saying the peson is a loser or an addict. He posted that he got misinformation on another site and was only relating his horrible experience to inform others if they got the same misinformation or if they took too much baclofen . Although the info may be of more relevance to alcoholism and those who have used baclofen titration (forgive use of "he" to mean "he/she). Don't most members here have or have had a problem? Maybe he only registered to post the one response. I did, because I was researching baclofen side effects and how much was too much as my cousin seemed to be having adverse effects and I was worried. She also take hydrocodone for a neck injury. His thread came up high on the links list so I read ALL the threads. We should be grateful for any posts that someone feels will be useful in dealing with drug or alcohol problems, side effects, and the consequences. Personally, I was on ambien for 10 years and took it faithfully and correctly, with no adverse effects. Then I became depressed due to financial reasons and started taking ambien as soon as I got home from work because I just didn't want to have to deal w/ finances more than I needed to, and like the poster, it was was handy. Being depressed, this seemed reasonable because at least I wasn't taking it work. OK so my logic sucked, but it usually does when one is depressed. My doctor then also prescribed xanax for my anxiety. This completely exacerbated the side effects of the ambien and gave me an easy out that I CHOSE to take. I was not physically addicted to either, but I was psychologically addicted. I was medicated for days on end, without realizing the combined effects were overlapping, and of course not being reasonably rational due the drug effects, I disagreed with friends who thought I might have a problem. My depression lasted several years as did my overuse. Thankfully I have been done with both the depression and the drugs for 8 years. My point? It is not our place to judge others Especially if they're posting information to try and be helpful.
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Old 04-14-2013, 07:15 AM
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I have a great respect for Baclofan and cannot take it. I tried a few years ago and had the most horrible reaction. I honestly thought that I was going to die one night. It was not on a very high dose either.

I do believe that we all have different responses to the drug. Had I taken the dose taken by the original poster, I would be dead.

This is a medication that has done wonders for many people, but it needs respect.
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