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  #11 (permalink)  
Old 01-20-2011, 08:27 PM
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Quote:
Originally Posted by beatle View Post
This is not medical advice, it is just my strong opinion based on my own research and my own experience:

I would not take acetaminophen (paracet, tylenol) ever under any circumstances if you have had above-average alcohol consumption (or any at all, really). It is a liver killer (this is a fact, although maybe a bit dramatically expressed here).

I know that ibuprofen is supposed to be processed by the kidneys, as is baclofen, but if you have not had any kidney problems in the past, I think this would be the better alternative (again, not medical advice). There are others who have posted that since both bac and ibuprofen are processed by the kidneys that perhaps taking ibuprofen with bac might increase the bac concentration in the blood. For me this is just a plus but it might be wise to monitor it a bit... Personally, I have had great results with ibuprofen for pain, even together with bac. I don't do it often, but it works fine for me. Just me, mind you. And 800mg doesn't sound outrageous to me. Just me, mind you.

Another thought, if you don't have any problems with aspirin, maybe that would work.
Thanks for weighing in beatle, I was hoping to hear from you. I do understand that it's your own opinion, and not medical advice, and thanks for stating that as well. While I'd heard that acetaminophen wasn't great for long term use, I had no idea it was so bad for your liver. I do recall hearing that it shouldn't be taken in conjunction with alcohol. Luckily I've recently had blood work done, and both my liver and kidney functions are excellent. In any case though, I will take your advice on the acetaminophen.
What do you think is the best way to monitor the bac + ibuprofen interaction? The study that terry posted mentioned drop in blood pressure - that is easy enough to monitor, I do that anyway every few days. I guess otherwise it's just monitoring how I feel overall? Disorientation is a given on bac, but I guess I'd know if it increased by a large measure all of a sudden. I can't believe that guy was showing signs of baclofen toxicity on just 20mgs a day due to the ibuprofen. Crazy stuff.

I'll try to keep the ibuprofen to a minimum in any case, for when the pain gets really bad. Sure is nice to be able to walk around right now w/out the pain!

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Switched at 180mgs of Baclofen on 1/31/11, and again on 10/8/11 at 200mgs.

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  #12 (permalink)  
Old 01-20-2011, 08:29 PM
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Quote:
Originally Posted by Bruunhilde View Post
Fucksocks? LOL That's a new one for me!
I don't remember who it was (maybe see) that first said it around here, but I loved it when I first saw it! Absolutely made me crack up. It's really an excellent expletive! Sure makes me feel better saying it, anyway!
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Switched at 180mgs of Baclofen on 1/31/11, and again on 10/8/11 at 200mgs.

Could've been a swan on a glassy lake, could've been a gull in a clipper's wake. Could've been a ladybug on a windchime, but she was born a dragonfly.
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  #13 (permalink)  
Old 01-20-2011, 08:54 PM
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That's great news about your blood tests. I wish I could say the same.

I don't know what would be the best way to monitor the bac+ibuprofen. I tried it before I had heard the warning here on MWO. But I had looked up the contraindications, and all I found were the usual CNS warnings (always "moderate"). I didn't notice any problem with it (I took 400 or 600mg) together with the bac. I just noticed that it helped my headache (something which is an astoundingly rare occurrence for me).

For me, it works fine. Everyone is different. I know from experience that I can take it if I need it. And although I am an anti-med, pro-natural healing person, sometimes, in a pinch, meds can maybe work better...?

(I also very occasionally take zolpidem for insomnia. I don't like to do it, but in a pinch...)
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Old 01-24-2011, 07:55 PM
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Hi Isolde,
Thanks for the tip on the gout. I have done some searches as you suggested, and your right there is a lot out there. This bout of gout (that rhymes) seems to have subsided, but next time i will take you up on your suggestion of Tart Cherry Juice. I hope your arthritis is OK and the apple cider vinegar does the trick.
I love natural remedies, so these tips are great. Thanks.
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2nd try of BAC started 6/9/10. Reached my switch at 210MG on 8/12/10. I weigh 68KG.
Have been Al Free since 19th November 2010. Extremely thankful and grateful.
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Old 01-24-2011, 08:16 PM
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There is this post by Zenstyle, if the question is still open, I haven't reread the thread...

http://www.mywayout.org/community/f2...ion-34919.html
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Old 04-27-2011, 10:33 PM
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Hi all,

When digging through medical literature be sure to differentiate between reviews and an an individual case report.

You could look at the article posted another way:

Patient was experiencing declining renal function (based on abstract, haven't read full article), THEN experienced baclofen toxicity?
Did patient have prior issues with renal function? What other medication was patient taking?

Since publication of this article in 1984 have there been other cases? Does one single case in 1984 mean you will also experience this complication?
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Old 04-28-2011, 08:24 AM
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Quote:
Originally Posted by Isolde View Post
I can't believe that guy was showing signs of baclofen toxicity on just 20mgs a day due to the ibuprofen.
What SpookyChan wrote:

Quote:
Originally Posted by SpookyChan View Post
When digging through medical literature be sure to differentiate between reviews and an an individual case report.

Patient was experiencing declining renal function (based on abstract, haven't read full article), THEN experienced baclofen toxicity?
Did patient have prior issues with renal function? What other medication was patient taking?
Since publication of this article in 1984 have there been other cases? Does one single case in 1984 mean you will also experience this complication?
It's very tempting to look at the cases reported about bac wherever we can find them. Unfortunately they are mostly related to people with some very, very serious health issues unrelated to bac.

But back to the pain-management thing! My tooth is KILLING me. Or rather, my mouth, where my tooth used to be. Ibuprofen is not offering enough relief, though come to think of it, I've only been taking 400mg. hmmm. nevermind. I'll up the ibuprofen.
The Tylenol 3 I was prescribed was next to worthless except for bouts of lousy sleep.
Which is good, because:
I agree with beatle about the acetomeniphen. Baaaad stuff even if you have normal liver function. (Not a doctor, don't know squat about medicine. Do know how to read, however.)

I haven't had a single SE due to taking ibuprofen, for the last 3 days, every 4 hours consistently. (And you all know I look for those damn SEs!) I'll let you know how 800mg every 4-6 works out.
Thanks Is.
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Last edited by Ne/Neva Eva; 04-28-2011 at 08:30 AM..
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  #18 (permalink)  
Old 04-28-2011, 11:00 AM
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I've taken ibuprofen recently post switch. I was avoiding it to be safe, but I had some bad pain from a foot sprain and gave it a shot. A couple of 600mg doses, a little less pain, nothing else to report...

I have been on baclofen for over a year and it's been 6 months since my switch @280, currently on 240. My kidneys checked out fine about 7 months ago, I'll have another lab done in a month.

Baclofen is chemically similar to GABA, a naturally occurring chemical in the body. Just from a little reading I find that 85% of baclofen is excreted unchanged by the kidneys, 15% is deaminated (metabolized) by the liver. And...hmmm....I'm reading that ibuprofen is also *mostly* metabolized by the liver (not the kidneys that I reported earlier - this is a great example of someone with an incomplete understanding of physiology/medicine posting some erroneous info). Anyhoo, I'll do some more research and report back if I can add something helpful.

I just deleted a couple of paragraphs describing my take on a reasonable way to take baclofen and NSAIDs. My bad. I'm not a freaking doctor. It's too easy to want to jump in here and play medical professional. I do it for myself with a lot of success so far, but I can't do it for others. I'm lucky enough to have access to healthcare at a free clinic in the US, but having a revolving door army of primary care doctors (I've seen about 12 in the last 2 years) has been an eye opener...Without exception *they all* give me different and *very often* conflicting information about various aspects of my health and treatment (without even coming close to mentioning high-dose baclofen). That experience alone has made me take an active part in figuring out how and why my body works and how to fix it when it's broken. Good luck out there folks. -tk

p.s. I tell *everybody* to stay away from acetaminophen

Last edited by terryk; 04-28-2011 at 11:01 AM..
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Old 04-28-2011, 01:26 PM
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I read about that guy. I believe he did have some renal failure prior to starting bac. I don't believe I've read any other case studies of issues, if renal failure wasn't already present.

Since, my research hasn't shown much on that front, I take ibuprofen for pain. Only when necessary. Acetaminophen doesn't work for me. It's either ibuprofen or toradol at home. Since toradol affects the kidney too, I stick with ibuprofen. Although, toradol does make me feel happy.......
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