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Old 01-20-2011, 04:12 PM
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Default Does baclofen nullify anti-inflammatories?

Alright, I've got a theory, and I wanted to see if anyone else had any input on it. I have arthritis in my big toe (no clue how this happened, btw, showed up at age 28 and was most likely caused by trauma, though I can't remember doing anything to it), and I take a curcumin supplement for it, which is a natural anti-inflammatory. From the time I began taking it, I had pretty much zero pain in my foot. For the past few months, the curcumin has been less and less effective. I have been switching brands and tried taking larger doses.
I recently also added astaxanthin (another powerful natural anti-inflammatory) in hopes that the combination would provide me some relief. I haven't experienced any improvement, in fact the pain has only gotten worse, so that I'm damn near limping at this point. I've also been dealing with really intense back pain over the past few weeks. It pretty much only goes away when I sleep. And the supplements I'm taking should really be helping with that as well. And I'm supplementing with Omega 3s, also natural anti-inflammatories. With all of this, I shouldn't be in this kind of pain.
My theory is that baclofen is making these supplements ineffective. I am about to go pick up some ibuprofen in an attempt to find SOME relief from the pain. It will be an experiment as well, to see if the bac prevents the ibuprofen from working too.

So, has anyone experienced anything at all like this with bac, or heard anything about bac having this sort of effect? I am torn between the desire to stay at a high dose to keep the cravings at bay, and the need to get some relief from the pain by trying to titrate down to see if lower levels of bac will let the anti-inflammatories do their job.
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Switched at 180mgs of Baclofen on 1/31/11, and again on 10/8/11 at 200mgs.

Could've been a swan on a glassy lake, could've been a gull in a clipper's wake. Could've been a ladybug on a windchime, but she was born a dragonfly.
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Last edited by Isolde : 01-20-2011 at 04:13 PM. Reason: spelling
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Old 01-20-2011, 04:23 PM
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Can't help with that, Is, my experience has been that bac relaxes my muscles and helps me with my hamstring which was giving me trouble before starting bac. Have you tried glucosamine? I don't know if anti-inflammatories or glucosomine are contra-indicated or not, you might want to look that up if you haven't already. A natural anti-inflammatory is fish oil, try 3-4 grams a day, that should help.
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Old 01-20-2011, 05:58 PM
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Quote:
Originally Posted by Bruunhilde View Post
Can't help with that, Is, my experience has been that bac relaxes my muscles and helps me with my hamstring which was giving me trouble before starting bac. Have you tried glucosamine? I don't know if anti-inflammatories or glucosomine are contra-indicated or not, you might want to look that up if you haven't already. A natural anti-inflammatory is fish oil, try 3-4 grams a day, that should help.
Yup, I'm already taking a high quality krill oil, as well as supplementing with additional Omega 3s. I also eat salmon and tuna each once a week. Not sure if glucoasmine would help with the arthritis and back pain, and I'm really not looking to add more to supplementation routine if I can help it. Thank you for the response though!
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Switched at 180mgs of Baclofen on 1/31/11, and again on 10/8/11 at 200mgs.

Could've been a swan on a glassy lake, could've been a gull in a clipper's wake. Could've been a ladybug on a windchime, but she was born a dragonfly.
~Clutch
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Old 01-20-2011, 06:27 PM
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From a previous post: Bac _ NSAIDs - any issues?

I believe that NSAIDS (non-steriod anti-inflammatory drugs) that are excreted by the kidneys (like ibuprofen) *can* cause baclofen blood levels to rise if your kidneys are over taxed. I've not taken any ibuprofen since starting baclofen just as a precaution. I can often take up to 2400mg+/day for various aches and pains.

Here's a link:

Baclofen toxicity associated with declining renal clearance after ibuprofen -- Dahlin and George 18 (10): 805 -- The Annals of Pharmacotherapy


A 64-year-old male with an incomplete spinal cord injury had been taking baclofen 20 mg tid for 2 1/2 months without side effects. His blood urea nitrogen and serum creatinine rose from 13 and 0.9 mg%, respectively, to 59 and 2.8 mg% after ibuprofen 600 mg tid was begun. The patient displayed baclofen toxicity, developing confusion, disorientation, bradycardia, and hypothermia. His blood pressure dropped and he complained of blurred vision. Ibuprofen discontinuation and fluid repletion corrected the renal indices. Rapid tapering of baclofen was accompanied by reversal of baclofen toxicity. Patients taking baclofen must be monitored closely for toxicity when declining renal function is present. Clinicians should be alert to the possibility of renal insufficiency developing when ibuprofen is initiated. This case demonstrates the potential for ibuprofen-induced renal insufficiency to reduce baclofen clearance, thereby leading to baclofen toxicity. Published reports of ibuprofen-induced renal insufficiency are reviewed and pertinent pharmacokinetics of baclofen discussed.


Your mileage may vary.
-tk

Last edited by terryk : 01-20-2011 at 06:30 PM.
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Old 01-20-2011, 06:45 PM
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Wow terry, thanks for posting that. Darnit, there goes my one hope of getting some relief. For some reason, I thought it was aciteaminophen that was contraindicated. Which I actually took some of the other day out of desperation and which had zero effect anyway.

I'll have to do some research to see if I can find out anything about baclofen and natural anti-inflammatories.
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Switched at 180mgs of Baclofen on 1/31/11, and again on 10/8/11 at 200mgs.

Could've been a swan on a glassy lake, could've been a gull in a clipper's wake. Could've been a ladybug on a windchime, but she was born a dragonfly.
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Old 01-20-2011, 06:56 PM
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Isolde,
It is funny you mention this. In the past month or so first my toe swelled up, then my ankle and now it is the ball of my foot at the base of my big toe. I thought it was just my gout acting up - A crusty old man's affliction I know. I used to get gout quite a bit when I was caning it with the drinking.
I am hobbling around at the moment due to the pain. I was at the doctor recently and got my Indometacin on a repeat subscription. This seems to help ease the pain a bit and bring down the swelling. I am not sure if you can get it in the US, but it helps me.
Maybe Terryk has something regarding the kidney function. I know for me, there is a real link between the Kidneys, impurities in the blood and gout.
I haven't been drinking as much water of late which I know doesn't help.
I hope the arthritis eases up a bit.
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2nd try of BAC started 6/9/10. Reached my switch at 210MG on 8/12/10. I weigh 68KG.
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Old 01-20-2011, 07:18 PM
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Quote:
Originally Posted by Full English View Post
Isolde,
It is funny you mention this. In the past month or so first my toe swelled up, then my ankle and now it is the ball of my foot at the base of my big toe. I thought it was just my gout acting up - A crusty old man's affliction I know. I used to get gout quite a bit when I was caning it with the drinking.
I am hobbling around at the moment due to the pain. I was at the doctor recently and got my Indometacin on a repeat subscription. This seems to help ease the pain a bit and bring down the swelling. I am not sure if you can get it in the US, but it helps me.
Maybe Terryk has something regarding the kidney function. I know for me, there is a real link between the Kidneys, impurities in the blood and gout.
I haven't been drinking as much water of late which I know doesn't help.
I hope the arthritis eases up a bit.
Full English
I came across a natural remedy for gout when I was researching arthritis - tart cherry juice concentrate, like this: Amazon.com: DYNAMIC HEALTH LABORATORIES INC 100% Pure Organic Certified Tart Cherry Juice Concentrate 16 oz: Health & Personal Care
If you do a search on this stuff and gout, you'll get a lot of information. I'm tempted to give it a shot for my arthritis, even though it isn't caused by gout. It sounds tasty! Especially if you add it to club soda or something fizzy like that.
I'm already drinking unfiltered apple cider vinegar in water 3 times a day and am about to start taking a tablespoon of honey with 1/2 tsp. of cinnamon in it every morning if the ACV doesn't help! Even if it doesn't work, at least it will be tasty! Though, for the record, I enjoy the apple cider vinegar. Supposed to be good for a whole host of issues, even if it doesn't help with the arthritis!
Thanks for the response, and good luck with the gout!
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Better Living Through Chemistry

Switched at 180mgs of Baclofen on 1/31/11, and again on 10/8/11 at 200mgs.

Could've been a swan on a glassy lake, could've been a gull in a clipper's wake. Could've been a ladybug on a windchime, but she was born a dragonfly.
~Clutch
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Old 01-20-2011, 07:27 PM
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I'd gone ahead and taken 800mgs of ibuprofen prior to reading terry's post. Damnit, it actually helps a lot with the arthritis! (Not affecting the nerve based pain in the back though.) Hmm, I wonder how much I can get away with daily without it causing repercussions...
Hm, considering the guy in the study was only taking 20mgs of baclofen and 600mgs of ibuprofen and had those extreme reactions, I'm guessing not much. =(
Fucksocks.
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Better Living Through Chemistry

Switched at 180mgs of Baclofen on 1/31/11, and again on 10/8/11 at 200mgs.

Could've been a swan on a glassy lake, could've been a gull in a clipper's wake. Could've been a ladybug on a windchime, but she was born a dragonfly.
~Clutch
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Old 01-20-2011, 07:41 PM
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Quote:
Originally Posted by Isolde View Post
So, has anyone experienced anything at all like this with bac, or heard anything about bac having this sort of effect? I am torn between the desire to stay at a high dose to keep the cravings at bay, and the need to get some relief from the pain by trying to titrate down to see if lower levels of bac will let the anti-inflammatories do their job.
This is not medical advice, it is just my strong opinion based on my own research and my own experience:

It's good to hear that it didn't have any effect, but I would not take acetaminophen (paracet, tylenol) ever under any circumstances if you have had above-average alcohol consumption (or any at all, really). It is a liver killer (this is a fact, although maybe a bit dramatically expressed here).

I know that ibuprofen is supposed to be processed by the kidneys, as is baclofen, but if you have not had any kidney problems in the past, I think this would be the better alternative (again, not medical advice). There are others who have posted that since both bac and ibuprofen are processed by the kidneys that perhaps taking ibuprofen with bac might increase the bac concentration in the blood. For me this is just a plus but it might be wise to monitor it a bit... Personally, I have had great results with ibuprofen for pain, even together with bac. I don't do it often, but it works fine for me. Just me, mind you. And 800mg doesn't sound outrageous to me. Just me, mind you.

Another thought, if you don't have any problems with aspirin, maybe that would work.

Last edited by beatle : 01-20-2011 at 08:15 PM.
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Old 01-20-2011, 08:17 PM
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Fucksocks? LOL That's a new one for me!
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