Welcome to My Way Out ! We’re glad you found us. Please remember this forum does not replace medical advice. We urge to you seek professional help, especially if you are experiencing symptoms of alcohol withdrawal. Look here for information about what to expect based on how much you're drinking. We hope you will register as a user in our forum and take advantage of the many rich resources here. Join our community today! It's fast, simple, anonymous and absolutely free!


Go Back   My Way Out Forums > Introduction & General Discussion > Topamax, Campral, Baclofen and Other Medications
Register Blogs FAQ Members List Calendar Mark Forums Read

Reply
 
LinkBack Thread Tools Display Modes
  #1 (permalink)  
Old 02-17-2010, 11:45 AM
Member
 
Join Date: Feb 2009
Posts: 2
Gallery: 0
Default How long does Naltrexone stays in your system?

Hi All,

It s been along time.

How much does naltrexone stays in your system?

For example if I am taking today 25mg and tomorrow 25 mg, will it stay for at least 12 h. Or do you feel the effect after 24 h?
Or it depends on how long do you take it.



Thanks.
Reply With Quote
  #2 (permalink)  
Old 02-17-2010, 12:06 PM
Member
 
Join Date: Sep 2009
Posts: 85
Gallery: 0
My Mood:
Default Welcome back

If you take 25mg it will stay in your system for 12 hours and if you take 50mg it will stay in your system for 24 hours, although it will still be washing out of your system the next day after the 24 hours. that is why you are recommended, if you are exercising, to wait another day before commencing any exercising.
Reply With Quote
  #3 (permalink)  
Old 02-17-2010, 12:09 PM
Member
 
Join Date: Sep 2009
Posts: 85
Gallery: 0
My Mood:
Default Also

it does not matter how long you are taking it, it is still going straight into your system. your are recommended to take 25mg for the first two times of taking it due to any side effects i.e. nausea.
Reply With Quote
  #4 (permalink)  
Old 02-17-2010, 12:36 PM
eight days a week's Avatar
Member
 
Join Date: Aug 2009
Location: Southeast England
Posts: 461
Gallery: 0
Default

Quote:
Originally Posted by Chocolate Mousse View Post
If you take 25mg it will stay in your system for 12 hours and if you take 50mg it will stay in your system for 24 hours, although it will still be washing out of your system the next day after the 24 hours. that is why you are recommended, if you are exercising, to wait another day before commencing any exercising.
I'm not sure about that part I've underlined Mousse, I thought in theory 25mg covers your endorphin receptors 100% for up to twelve hours, but it will stay in your system for much longer than that. If that's correct then, say you need painkillers for surgery, you would need a good few wash-out days after having 50mg, unless the medical staff were alerted and gave you non-opioid alternatives.
__________________
(Not able to come here much these days, if I don't reply to something or you'd like to talk please PM me and I'll see it in my email inbox. Best wishes to all! )
Reply With Quote
  #5 (permalink)  
Old 02-18-2010, 07:03 AM
Member
 
Join Date: Sep 2009
Posts: 85
Gallery: 0
My Mood:
Default 8

Yes I thought the 25mg will cover your endorphin receptors 100% for 12 hours the same as 50mg for 24 hours but that both take another day to wash out of your system? If Im wrong I stand corrected! Please let us know 8, I don;t have the book with me here..
Reply With Quote
  #6 (permalink)  
Old 02-18-2010, 10:38 AM
eight days a week's Avatar
Member
 
Join Date: Aug 2009
Location: Southeast England
Posts: 461
Gallery: 0
Default

Ah, I wouldn't like to offer any medical advice Mousse, hopefully someone with a good understanding will offer their thoughts, but I personally think you have the right kind of idea there. I guess it will depend on the physiology and metabolism of each person, too.
__________________
(Not able to come here much these days, if I don't reply to something or you'd like to talk please PM me and I'll see it in my email inbox. Best wishes to all! )
Reply With Quote
  #7 (permalink)  
Old 02-18-2010, 03:39 PM
eight days a week's Avatar
Member
 
Join Date: Aug 2009
Location: Southeast England
Posts: 461
Gallery: 0
Default

Quote:
Originally Posted by GettingBetter View Post
If you look up information about naltrexone you'll see a reference to something called it's "half life" which is the amount of time it takes it to decrease to half it's original strength. Wikipedia says naltrexone's half life is 4 hours but I've seen other sources give a higher number. I think if we want to figure out how long naltrexone blocks the opioid-receptors for we we need to know how much naltrexone the body needs to get that effect (if for instance that number was say 12.5 mg, 50 mg would be effective for 8 hours), and I don't know that. What I can say though is that (if my understanding is correct) 50 mg decays to 25 mg in 4 hours, so a 50 mg pill will give you 4 hours more of the effect than a 25 mg pill will.
I don't think we can trust Wikipedia on such an important topic. Dr Eskapa I believe says that 50mg should block up to 100% of the opioid receptors for up to 24 hours, which seems to totally contradict that Wikipedia info. That would mean days before it would be totally out of your system, (and thus days before any opioid-based pain relief medication would work as it should if, gods forbid, one was in an emergency room setting, for example after an accident). Perhaps someone should email Dr Eskapa to clear this up?
__________________
(Not able to come here much these days, if I don't reply to something or you'd like to talk please PM me and I'll see it in my email inbox. Best wishes to all! )
Reply With Quote
  #8 (permalink)  
Old 02-18-2010, 04:12 PM
Member
 
Join Date: Feb 2010
Location: Oregon
Posts: 12
Gallery: 0
Default

I don't know the answer but I write the date I last took one on the medic-alert card in my wallet in hopes that if necessary, medicos will be able to sort it out.
__________________
Sinclair Method experience - week by week
Reply With Quote
  #9 (permalink)  
Old 02-18-2010, 04:36 PM
eight days a week's Avatar
Member
 
Join Date: Aug 2009
Location: Southeast England
Posts: 461
Gallery: 0
Default

GettingBetter, with all due respect that seems to be all speculation on your part based on a figure given by Wikipedia, which I don't think is at all helpful. If it did only take 0.5mg (just your example) to block receptors then we would be told to take far less than one 50mg tablet if we are drinking for very much less than 24 hours, but we are not. There's the contradiction.

Quote:
Originally Posted by PlainVanilla View Post
I don't know the answer but I write the date I last took one on the medic-alert card in my wallet in hopes that if necessary, medicos will be able to sort it out.
Excellent advice that I would urge everyone who takes Nal to follow
__________________
(Not able to come here much these days, if I don't reply to something or you'd like to talk please PM me and I'll see it in my email inbox. Best wishes to all! )
Reply With Quote
  #10 (permalink)  
Old 02-18-2010, 05:02 PM
eight days a week's Avatar
Member
 
Join Date: Aug 2009
Location: Southeast England
Posts: 461
Gallery: 0
Default

Thank you for the sources GettingBetter, but still I would rather this is something cleared up by either Dr Eskapa or Dr Sinclair, or another doctor with expert knowledge of Naltrexone use.

And I'm sure that Wikipedia can be correct, I'm just personally not willing to trust it alone on what is potentially a life-threatening (if you have an accident and are taken to ER) scenario, and they give you opioid-based medications.

The contradiction is that all of the studies, all of Dr Sinclair's research and practical experience, and all of Dr Eskapa's book is based on taking 50mg each and every time you drink. If your speculation's true (that you need only a fraction of the dose if you're drinking in a far shorter timeframe than 24 hours) then do you not think they would have touched on that at some point in the years they've been working with The Sinclair Method?

Quote:
Originally Posted by PlainVanilla View Post
I don't know the answer but I write the date I last took one on the medic-alert card in my wallet in hopes that if necessary, medicos will be able to sort it out.
Quoted again because I think this is such important information.
__________________
(Not able to come here much these days, if I don't reply to something or you'd like to talk please PM me and I'll see it in my email inbox. Best wishes to all! )

Last edited by eight days a week; 02-18-2010 at 05:04 PM..
Reply With Quote
Reply


Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On




All times are GMT -2. The time now is 09:26 AM.


Powered by vBulletin® Version 3.8.3
Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.
Search Engine Optimization by vBSEO 3.1.0

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32