Alternatively to alcohol on the way at last

[scotskev81]

I take gaba NOW brand. I take two 500mg capsules at bedtime and one in the morning. This had been my routine since my doctor recommended in 2015. I’m not sure about the connection between gaba and alcohol dependence!?

How do these gaba NOW pills make you feel?

[techie]

How do these gaba NOW pills make you feel?

they just calm the nervous system. I’m not aware of any particular sense of them!

[scotskev81]

they just calm the nervous system. I’m not aware of any particular sense of them!

Thanks. They legal to buy in UK?

[Mulburry]

I take gaba NOW brand. I take two 500mg capsules at bedtime and one in the morning. This had been my routine since my doctor recommended in 2015. I’m not sure about the connection between gaba and alcohol dependence!?

GABA-A is one of the main neurotransmitters that alcohol effects and the changes in brain chemistry of the GABA system are one the major causes of whithhdrawal symptoms. I was under the impression though, that just taking Gaba supplements would not have much of an effect on the gaba systme in the brain because it does not cross the blood brain barrier easily?

[scotskev81]

GABA-A is one of the main neurotransmitters that alcohol effects and the changes in brain chemistry of the GABA system are one the major causes of whithhdrawal symptoms. I was under the impression though, that just taking Gaba supplements would not have much of an effect on the gaba systme in the brain because it does not cross the blood brain barrier easily?

No idea about that I'm afraid.

This Sentia had a little effect on me but was very mild.

[Mulburry]

This Sentia had a little effect on me but was very mild.

Something that affects just GABA won't really give you the "buzz" of drinking though (as Al also effects many other receptors such as dopamine, serotonin, endogenous opiods etc.), it may just have a slightly sedating/calming effect (similar to a very mild version of valium for example). But hey, if it's enough to fool you into thinking you're "drinking", it's better than actually drinking...

[scotskev81]

Something that affects just GABA won't really give you the "buzz" of drinking though (as Al also effects many other receptors such as dopamine, serotonin, endogenous opiods etc.), it may just have a slightly sedating/calming effect (similar to a very mild version of valium for example). But hey, if it's enough to fool you into thinking you're "drinking", it's better than actually drinking...

Yes that's what I was hoping it would do until the real one comes out in a few years.

[scotskev81]

Functional Alternatives to Alcohol - PMC

Detailed science document

[scotskev81]

Co-founder David Orren, out enjoying some SENTIA. ⁠
⁠
David is an internationally-experienced business leader and coach, focussing on companies with disruptive innovation strategies.

From 2016, David has been working to revolutionise the adult social drinking market, working with world-renowned neuropsychopharmacologist, Professor Dave Nutt, to create and bring to market Alcarelle, a novel biomimetic GABAergic compound designed to give adult drinkers what they want from alcohol, without the alcohol

David has developed the business from its biochemical research origins to an organisation ready to take Alcarelle through the US FDA GRAS Dossier process.

En route, David and his team have built a botanical proof-of-concept drinks business, Sentia Spirits, which has taken the market by storm as the only science-based functional beverage currently available. Sentia shows the market what is possible with GABAergic drinks, and sold over 10,000 bottles in Jan 2023, making it the highest performing botanical spirit on Amazon UK.

Alcarelle will go through the FDA regulatory process during 2023 to 2027, entering the US market as an ingredient sold to the Drinks Industry in 2028, then expanding into the EU during 2029, and Japan in 2030.

[scotskev81]

2027 can't come quick enough. 😭😭