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Thread: Gabapentin

  1. #121
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    Gabapentin

    spiritwolf333;1617025 wrote: Sounds like you and NE have gabapentin covered. Someone should inform Dr. George Koob -new director at the NIH-Alcohol and Abuse of your and Ne's Wiki findings.

    Dr. Koob headed up the research for gabapentin at the Scripps Institute. Furthermore, Dr. Koob and Dr. Ameisen had several conversations regarding Baclofen. Dr. Ameisen was well pleased that Dr. Koob was aware of baclofen and that Ameisen had done a self-study. Also, Scripps has performed research regarding alcoholism using both baclofen and gabapentin.
    No I totally get that - and am not trying to start an argument. Just saying that I know enough of the brain chemistry to know that baclofen is the ONLY thing to do what it does. Baclofen removes cravings for alcohol, I've experienced it, but it doesn't really do much else now does it? Gabapentin, from what it sounds like, works in treating alcoholism by treating the SIDE EFFECTS of NOT DRINKING, the depression, anxiety, insomnia, etc. And so makes it easier to remain abstinent because the person is not feeling all the crap that generally leads to (re)lapse. So by removing some of the triggers that lead to drinking and the effects of not drinking, people don't drink so much, and if their goal is abstinence then that's all that much easier.

  2. #122
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    Gabapentin

    squeezed;1617431 wrote: It's easy to over-focus on brain receptors and what not, but alcohol hits lots and lots of neural pathways. It seems unlikely that addressing one specific receptor would be a magic bullet.

    It is also simplistic to say that alcoholism is a problem with brain chemistry, since everything we do affects brain chemistry. As humans, we have vastly more extrinsic input into our behavior than ,say, rats; it is difficult to extrapolate rat behavioral experiments to humans.

    Bottom line about bac, or gabapentin, or anything else works for alcoholism or not: large clinical studies are needed. In the meantime, we are all free to try them for ourselves (after due diligence). I have used several myself.

    Even the best results for alcoholism meds aren't that great. People enthuse about the headline 60%, or 75%, or whatever success rate of a study or claim. Underneath the hood the results are less spectacular.

    One example: As-needed nalmefene (basically TSM) was approved in Europe last year on the basis of its 60-65% success rate in large trials. But the success on placebo was 50%. So the Number-Needed-to- Treat (NNT) was close to the 9 for Antabuse, naltrexone (non-TSM), Campral, and even the latest gabapentin study from Scripps. That is: the vast majority will not benefit more than placebo.

    Also, the typical follow-up for these studies is mere months. Would the results be better or worse after a year? Who knows? When I was doing TSM, there were posters on their forum insisting that people should keep going even after 9 months without much difference.

    People should try meds for alcoholism, because they do work. But they shouldn't expect miracles in all - or most - cases. And don't blame yourself if a particular med doesn't work for you.
    Hi Squeezed -you know, you seem like a highly intelligent person. Your information appears both valid and insightful. Seems as though you can (and do) add a lot to the medical side of the forum. What I don't get is some of your more provocative posts. No, not individual posts directed at anyone -just ... well you get it. It almost appears as if you are somehow disgusted with the former direction of the forum and are taking some type of stand? This, in and of itself is not a bad thing -especially if its purpose is to enlighten and not harm. Anyway, thank you for your solid input.

  3. #123
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    Gabapentin

    Hi JD -I just found this video on youtube from the Scripps Institute regarding Gabapentin. Thanks.

    http://www.youtube.com/watch?v=ty91VxjEHpc[/video]]

  4. #124
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    Gabapentin

    Hey all,

    I thought I give a little input to this conversation, as I rarely post. However, this thread interested me and so did the Scripps study. I tried Topamax, the TSM method, and baclofen. I was way too doped up feeling on Topa, TSM had no real impact on me one way or another, no side effects either. Baclofen, at times I felt like my drinking diminished a bit. I got up to around 275mg/day and unfortunately, the side effects ultimately were just too much to handle. I got a script from Dr. Levin (if I remember correctly) and even consulted with him regarding the side effects. He had never heard of some of the side effects I was experiencing. To me it was like the worst allergy attack ever. Constant eye watering, nasal congestion, along with the other common complaints like tiredness. I also vomited during the day twice at the higher dosages. This may have occurred from a double does, as I sometimes couldn't remember if I had taken a does or not. Or maybe, I'm just allergic to the stuff. So, here I am getting all excited about Gabapentin. I order like a month supply at the 1800mg/day level. I started last week. Titrated up adding 300mg/day until 1800mg. I've been at 1800mg/day for about a week now or 4 or 5 days. I ordered from gold pharma, the Park Davis Neurontin 300 caps (same drug gabapentin). I can say without a doubt I am experiencing no side effects. I feel exactly the same. I don't know how long one might have to continue before they see some benefits. Who knows, maybe it takes a month. But for now I think any reduction in my drinking is modest at best. I'm even fooling around with dosage times. For me 4pm is the time of day I get the itch, so now I am trying 600mg/morning, 900mg at 3PM, and 300 and bedtime to see if I get any reduction during drinking hours. That's it. I'll post more if I begin to see some value. Otherwise, I hope your brain chemistry has better luck.

  5. #125
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    Gabapentin

    I kinda got here late, never heard of gabapentin, the stuff was prescribed for my restless leg syndrome that I only get after prolonged drinking and then back to sobriety. All I can say is that for me this stuff works great, no restless legs, sleeping very well, feel great, still looking forward to a few beers next month, but no jonesing of any kind. I've been at about 600 to 900 milligrams a day for the last 3 months...I like this cheap very mellow drug, and 27 straight days AF so far this time around.

  6. #126
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    Gabapentin

    squeezed;1618026 wrote: I don't have an agenda. I've tried many of the meds advocated here, and none of them worked for me. (Well, Bac dropped my drinking, if I was willing to stay in bed all day and not work.) Also, no AA for me. So, basically I am pretty cynical about all these miracle cures (having read the studies).

    After reading the newer posts (in other threads), I think I will just step back. It is exciting though to see the unbridled enthusiasm of the newbies.

    Good luck.
    Squeezed -thanks for the reply. Did you ever try not drinking while taking baclofen? I know, sounds like bullshit -but really, did you? And many of us do understand about the AA thing. And just having read the studies -well, don't stop there. You seem a hell of a lot smarter than me so I think I will just stop. But I do believe one thing; when you do find what works for you, then you will make one heck of proponent for that chemical.

  7. #127
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    Gabapentin

    AJ22;1617860 wrote: Hey all,

    I thought I give a little input to this conversation, as I rarely post. However, this thread interested me and so did the Scripps study. . For me 4pm is the time of day I get the itch, so now I am trying 600mg/morning, 900mg at 3PM, and 300 and bedtime to see if I get any reduction during drinking hours. That's it. I'll post more if I begin to see some value. Otherwise, I hope your brain chemistry has better luck.
    Looking forward to your updates

    Balboa45;1618275 wrote:
    I kinda got here late, never heard of gabapentin, the stuff was prescribed for my restless leg syndrome that I only get after prolonged drinking and then back to sobriety. All I can say is that for me this stuff works great, no restless legs, sleeping very well, feel great, still looking forward to a few beers next month, but no jonesing of any kind. I've been at about 600 to 900 milligrams a day for the last 3 months...I like this cheap very mellow drug, and 27 straight days AF so far this time around.
    Balboa - congrats on the 27 days. Please keep posting regarding you Gabapentin progress. I know JD is very interested also.

  8. #128
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    Gabapentin

    spiritwolf333;1618322 wrote: Looking forward to your updates



    Balboa - congrats on the 27 days. Please keep posting regarding you Gabapentin progress. I know JD is very interested also.
    Your quite welcome Wolf, the way I look at it anything that's good is good. I'm going to keep the gabapentin around as just another useful tool, really like it so far, I can't even tell I'm taking it except for the fact I'm more mellow, it has no side effects and doesn't have any effect on my intense exercise routine. I'm going to have a few pops next month, maybe 3 or 4 days of drinking, I have a case of Heineken out in the garage and some Maker's Mark that I'm looking forward to then hopefully another 25 or so sober days for February. My AF goal for 2014 is 240 days, and I need a good head start.

    You guys keep posting up the progress as I'm interested as well.

    Thanks B-45

  9. #129
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    Gabapentin

    squeezed;1618688 wrote: I did tried to cut down on alcohol during my bac phase. Did I try for abstinence? No. Is there a difference? I don't know.

    When I read papers on alcoholism studies, what really strikes me is how many subjects on *placebo* get better: 25-50% ! Granted, the follow-up periods are short, but we don't know what happens to the med groups 2-5 years either.

    Actually, I do drink much less now. No meds. No AA. Nothing. Something to do with getting older : ) .
    LOL -On the getting older -drinking less part. I can only post from my experience and that was: Remaining abstinent while titrating up on baclofen was well worth the effort. Don't get me wrong; it was still hell -the not drinking, the feeling lost, the depression, -all, were calling on me to have a drink and all would be ok. Once thru this stage, life began to take on a new meaning and baclofen took over -allowing me to stay calm thru the extreme ups and downs.

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    Gabapentin

    squeezed;1618719 wrote: I am very happy that baclofen is working for you, and others.

    I am going to give it a rest. TSM, or gabapentin, or AA work for many people too
    . So does doing nothing but just deciding not to drink anymore. Is HDB better? By pointing out that *no* med regiment - yes, including HDB - has been shown to be much good, I get vitriol directed my way.

    Thanks for being a reasoned poster here. I wish you the best of luck.
    Again, thanks for the post. I do understand, or least I think I understand, where you are coming from. I can only speak for me as far as HDB working -and yes it did and does work. As you say, the other methods can and do work also -those methods just did not work for me.

    The last method you mentioned -just do nothing and stop drinking; well, that option lost its chance with me many-many years ago. Someone who has progressed to the unfortunate realm of "alcoholism" lost that choice many moons ago. Unfortunately, the real fact (at least for an alcoholic like me) for me was that death was a much a better option than stopping alcohol. And that is the reality of for most "real" alcoholics and that is the sadness the world and its families must deal - and that is one reason that MyWayOut is so potentially beneficial to those in the final stages of alcoholism.

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