I started at 25mg and didn't notice any reduction in cravings at all. I quickly went to 50mg. Still no reduction. Impatient as I am, I jumped right to 100 (within a week). I noticed a small reduction in cravings and was drinking less. I did have the tingling in the hands and feet, but no big deal. I'm on antidepressants, so no problem there. Definitely tired, but not sure if that is because of my hypothyroidism (just diagnosed). Still think my doc started me on way too low of a dose for that. A week later, I'm up to 200 mg. I know that was a fast progression to 200......but I think I found my right dose. I can barely even finish a glass of wine now. I still "want" to drink, but I can't. It's weird. I have this battle in my mind at the end of the day. Do I want a glass of wine or don't I? At least it's a battle now. Before, there was no question....I had to have it. Now, I pour the glass of wine, and most of it just sits there. That has NEVER happened to me before. I've had the same bottle of wine in the fridge for the past week. Oh....and beer just tastes awful! and I do love my beer


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