Has anyone tried Ondansetron to reduce/eliminate their drinking?
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Ondansetron
it looks interesting, but that medication looks prohibitively expensive to use daily.
The drug is a serotonin 5-HT3 receptor antagonist, so perhaps other drugs that block the receptor work too. I found this pubmed link
The role of 5-HT3 receptors i... [CNS Neurol Disord Drug Targets. 2008] - PubMed - NCBI
Preclinical findings indicate that antagonism of the 5-HT3 receptor in the ventral tegmental area, nucleus accumbens or amygdala reduces alcohol self-administration and/or alcohol-associated effects01-01-2014 - Indifference reached, success with high dose Baclofen 295mg.
Baclofen prescribing guide
Baclofen for alcoholism - Consolidated Information - Studies, prescribing guides, links -
Ondansetron
It's a generic now so 56 4mg tablets only cost me about ?15 with a private prescription. Two tablets per day.
I've already noticed two things - the horrible nausea that I feel in the morning is much better - and I don't get the "aaaaaaah" feeling when I have my first drink after work.
Let's see how it goes. I have decided to titrate down on baclofen as it was making me a non-functional human being.Comment
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